fbpx

Coat Colour E-locus (5 variants) H791

69,00 €

*
*

Included tests

H632 - Coat Colour E-Locus - e2 (Australian Cattle Dog cream colour variant)
H818 - Coat Colour E-locus - Em (Melanistic Mask)
H783 - Coat Colour E-locus - e3 (Husky pale yellow/white variant)
H784 - Coat Colour E-locus - Eg (Grizzle)
H734 - Coat Colour E-locus - e1 (red/yellow)
 

Specifications

Breeds

All Breeds

Organ

None

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

General Information

Coat colour in dogs is controlled by a wide range of different genes working together. These genes are often referred to as ‘loci’. The Extension, or E-Locus, corresponds to the gene ‘melanocortin 1 receptor’ (MC1R), which is involved in the regulation of pigment production. Active MC1R causes a cell to “switch” from the production of phaeomelanin (yellow/red pigment) to eumelanin (black/brown pigment). Mutations affecting the E-locus often result in a lightening of the coat, from black/brown to red/yellow/white.

The wild-type form of the E-Locus is designated as ‘E’. Dogs with at least one E-allele are able to produce dark coat pigment. However, this darker coat may be further affected by other coat colour loci such as the B-Locus and D-Locus.

The recessive mutations designated as ‘e’ interrupt the function of MC1R. Dogs with two e-alleles have lighter coats. Depending on the breed, their colour may be described as red, yellow, apricot, cream or white. There are several different variants of the e-mutation: e1, e2, and e3. These variants are specific to different breeds, but any combination of two e-alleles results in the loss of dark pigment. 

There are also several dominant E-locus mutations, which instead affect the distribution of dark pigment. The Grizzle mutation, EG, is specific to the Afghan Hound and Saluki, and results in the dark-topped pattern known as Grizzle or Domino. The Melanistic Mask mutation, EM, causes a mask-like darkening of the fur around the face and muzzle. However, a Melanistic Mask may be invisible if the rest of the dog’s coat is similarly dark.

The E-locus mutations have different degrees of dominance over each other. EM is dominant over all other variants, followed by EG. The three e mutations are equally recessive.