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X-SCID H745

56,87 €

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Background

The X-linked inherited disease Severe Combined Immune Deficiency (SCID) is characterised by profound defects in cellular and humoral immunity and is inevitably fatal by 4 months of age. Due to an almost complete absence of the immune system, young animals die due to a variety of infections.

Test specific information

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Age

Symptoms will develop at a young age. Within a few hours to a maximum of several weeks after birth, the characteristics that go with these genetic effects will become visible.

Throughput

Normally the result can be expected within 15 working days. This turn-around-time starts when both the sample and the fully filled-out and signed submission form have been received.

Location of disease or trait

This disease leads to reduced immunity. Depending on the disease, the immune system may be completely absent.

Breed dependence

This DNA test is available for the following breeds: Welsh Corgi.

Sample type

For this DNA test we accept the following materials: Blood EDTA, Swab, Blood Heparin, Semen, Tissue. Please contact PharmaDNA if you wish to submit other material as listed.

Result

The following results are possible for a female: the mode of

Inheritance

is based on recessive or dominant patterns.The following results are possible for a male: - A male animal has the sex chromosome Y and a healthy allel. When used in breeding, this animal will not become affected by the disease, nor will the disease be inherited to the next generation. - A male animal has the sex chromosome Y and a disease allel. When used in breeding, this animal will become affected by the disease. Also, male offspring will receive the Y-chromosome, whereas female offspring will receive the disease allele.

Inheritance

The disease is inherited in an X-chromosomal manner. This means, that female individuals can be free (homozygous normal), affected (homozygous affected) or carrier (heterozygous). Male individuals carry only one copy of the X-chromosome, which results in the effect that male carriers will also be affected. Female carriers may spread the disease in a population without showing symptoms themselves. Because of this, it is extremely important to identify carriers correctly to prevent spreading of a disease.

Severity of Disease

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